This three-year project will encourage, equip and enable researchers in Latin America, especially early career scholars with the potential to become future project and academic leaders, to engage in big questions at the intersection of contemporary science, philosophy and theology. The strategy will be to raise detailed challenges under three headings: the origin and concept of life; the brain, the mind, and the human person; and the place of the person in the cosmos. By means of three workshops, a final conference, ten project awards, ten Oxford Templeton visiting fellowships to Latin America, and ten Oxford Templeton Latin America Scholarships, the project will provide outstanding opportunities for at least 150 participants across the region to engage directly with leading international academics and to develop ideas and publications addressing these challenges. At least 5000 further persons are expected to engage indirectly by means of activities developed by grant and award recipients, and broader awareness of key ideas is anticipated by at least 200,000 persons as a result of online and media outputs. Within 5-8 years of the project start, at least 15–20 publications/year are expected in established regional journals, and at least 40 new research connections, overcoming regional isolationism. The skills required and issues raised in this interdisciplinary work of this kind are also expected to help shape undergraduate and graduate teaching in Latin America HEIs, and specialized research centers and academic positions within HEIs may also be established. Over the longer term, the expectation is that these outcomes will help deepen and extend throughout Latin America the capabilities required for advanced, scientifically-informed engagement with key philosophical, religious and theological questions. As a result, within 5-8 years of the project start, JTF should be receiving regularly at least 20 OFIs/year, and strong full proposals from the region.