This project aims to bring before a wide public audience the best and latest perspectives on some of the Big Questions in science, philosophy, and theology. The project has two parts. The first part of the project concerns one of the overarching Big Questions: What is the relationship among information, matter, and life? In our widely respected quarterly journal *The New Atlantis*, we will commission, edit, and publish a special issue addressing aspects of this topic, drawing on research from cosmology and physics, biology, cognitive science and psychology, information theory, philosophy of mind, philosophy of science, and other fields. The second part of the project will consist of publishing in other issues of the journal special sections of essays dedicated to exploring other Big Questions. These special sections will address at least three of the following five topics: (1) exoplanets, astrobiology, and the human and theological meaning of life beyond Earth; (2) new developments in the scientific and philosophical investigation of free will; (3) the idea of miracles in modern theology, philosophy, and science; (4) the place of cooperation and altruism in human origins and in the evolutionary origins of life more generally; (5) and the integrity of scientific research. In addition to commissioning, editing, and publishing the special issue and special sections, we will publicize this material to bring it before the widest possible lay readership, and especially to promote it to students, academics, and policymakers. The output of this project will be a special issue of five or more essays published in *The New Atlantis* in 2016, as well as at least three additional special sections of the journal published in issues of *The New Atlantis* in 2015 and 2016. Ranging from metaphysics to materiality to morals, this project will foster interdisciplinary dialogue about how different scientific fields address the Big Questions.