This is a four-pronged project involving major fundamental questions in physics today. I am requesting support that will allow me to continue my research into gravitation, quantum field theory and quantum gravity, particle physics and cosmology. Much of the grant money would be used to hire postdoctoral fellows to help further this research, and to provide travel research funds for myself and collaborators. I have been developing alternative models to the established physics paradigms: modified gravity (MOG) without dark matter, an alternative particle physics theory that does not have a Higgs particle, a quantum gravity theory that eliminates the problematical singularities in black holes and at the beginning of the universe, and an inhomogeneous cosmology that explains the apparent acceleration of the universe without any dark energy. Astronomical and cosmological experiments now underway could verify my gravity work. In addition, I am making predictions in my particle physics theory that can be tested at the LHC and Tevatron accelerators. The activities of the project include at least 5 papers published in peer-reviewed journals, at least 8 talks at conferences and other venues, a dedicated workshop on particle physics experimental results to be held at the Perimeter Institute and a popular physics book published by Oxford University Press. As for the enduring impact of the project, if even one of my alternative models turns out to be correct, this would have far-reaching consequences for the future of physics and for human society in general, as it would change basic assumptions about nature.